What
is the most important information I should know about sildenafil?
* Do not take sildenafil if you are also using a nitrate drug
for chest pain or heart problems. This includes nitroglycerin (Nitrostat,
Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate
(Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate
(Imdur, ISMO, Monoket). Nitrates are also found in some recreational
drugs such as amyl nitrate or nitrite (“poppers”). Taking
sildenafil with a nitrate medicine can cause a serious decrease
in blood pressure, leading to fainting, stroke, or heart attack.
* If you become dizzy or nauseated, or have pain, numbness, or tingling
in your chest, arms, neck, or jaw during sexual activity, stop and
call your doctor right away. You could be having a serious side
effect of sildenafil.
* Do not take sildenafil more than once a day. Allow 24 hours to
pass between doses.
* Contact your doctor or seek emergency medical attention if your
erection is painful or lasts longer than 4 hours. A prolonged erection
(priapism) can damage the penis.
* A small number of patients have had a sudden loss of eyesight
after taking sildenafil. This type of vision loss is caused by decreased
blood flow to the optic nerve of the eye. It is not clear whether
sildenafil is the actual cause of such vision loss. Sudden vision
loss with sildenafil use has occurred most often in people with
heart disease, diabetes, high blood pressure, high cholesterol,
or certain pre-existing eye problems, and in those who smoke or
are over 50 years old.
* Stop using sildenafil and get emergency medical help if you have
sudden vision loss.
What is sildenafil?
* Sildenafil relaxes muscles and increases blood flow to particular
areas of the body.
* Sildenafil is used to treat erectile dysfunction (impotence) in
men. Another brand of sildenafil is Revatio, which is used to treat
pulmonary arterial hypertension and improve exercise capacity in
men and women.
* Sildenafil may also be used for purposes other than those listed
here.
What should I discuss with my healthcare provider before taking
sildenafil?
* Do not take sildenafil if you are also using a nitrate drug
for chest pain or heart problems. This includes nitroglycerin (Nitrostat,
Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate
(Dilatrate-SR, Isordil, Sorbitrate), and isosorbide mononitrate
(Imdur, ISMO, Monoket). Nitrates are also found in some recreational
drugs such as amyl nitrate or nitrite (“poppers”). Taking
sildenafil with a nitrate medicine can cause a serious decrease
in blood pressure, leading to fainting, stroke, or heart attack.
* A small number of patients have had a sudden loss of eyesight
after taking sildenafil. This type of vision loss is caused by decreased
blood flow to the optic nerve of the eye. It is not clear whether
sildenafil is the actual cause of such vision loss. Sudden vision
loss with sildenafil use has occurred most often in people with
heart disease, diabetes, high blood pressure, high cholesterol,
or certain pre-existing eye problems, and in those who smoke or
are over 50 years old.
* Before taking sildenafil, tell your doctor if you have:
o heart disease or heart rhythm problems;
o a recent history (in the past 6 months) of a heart attack, stroke,
or heart rhythm disorder;
o congestive heart failure;
o high or low blood pressure;
o coronary artery disease;
o liver disease;
o kidney disease;
o a blood cell disorder such as sickle cell anemia, multiple myeloma,
or leukemia;
o a bleeding disorder such as hemophilia;
o a stomach ulcer;
o retinitis pigmentosa (an inherited condition of the eye);
o a physical deformity of the penis (such as Peyronie's disease);
or
o if you have been told you should not have sexual intercourse for
health reasons.
* If you have any of these conditions, you may not be able to use
sildenafil or you may need a dosage adjustment or special tests
during treatment.
* FDA pregnancy category B: This medication is not expected to be
harmful to an unborn baby. Do not use sildenafil without telling
your doctor if you are pregnant or plan to become pregnant during
treatment.
* It is not known if sildenafil passes into breast milk or if it
could harm a nursing baby. Do not use this medication without telling
your doctor if you are breast-feeding a baby.
How should I take sildenafil?
* Take sildenafil exactly as it was prescribed for you. Do not
take it in larger doses or for longer than recommended by your doctor.
* Revatio is usually taken three times each day, about 4 to 6 hours
apart.
* Viagra is usually taken only when needed, 30 minutes to 1 hour
before sexual activity. You may take it up to 4 hours before sexual
activity. Do not take Viagra more than once per day.
* Viagra can help you have an erection when sexual stimulation occurs.
An erection will not occur just by taking a pill. Follow your doctor's
instructions.
* If you become dizzy or nauseated, or have pain, numbness, or tingling
in your chest, arms, neck, or jaw during sexual activity, stop and
call your doctor right away. You could be having a serious side
effect of sildenafil.
* Store this medication at room temperature away from moisture and
heat.
What happens if I miss a dose?
* Viagra is used as needed, so you are not likely to miss a dose.
* If you miss a dose of Revatio, take the missed dose as soon as
you remember. If it is almost time for your next dose, skip the
missed dose and take the medicine at the next regularly scheduled
time. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
* Seek emergency medical attention if you think you have used
too much of this medicine. Symptoms of a sildenafil overdose may
include chest pain, nausea, irregular heartbeat, and feeling light-headed
or fainting.
What should I avoid while taking sildenafil?
* Avoid drinking alcohol, which can increase some of the side
effects of sildenafil.
* Avoid using other medicines to treat impotence, such as alprostadil
(Caverject, Muse, Edex) or yohimbine (Yocon, Yodoxin, others), without
first talking to your doctor.
What are the possible side effects of sildenafil?
* If you become dizzy or nauseated, or have pain, numbness, or
tingling in your chest, arms, neck, or jaw during sexual activity,
stop and call your doctor right away. You could be having a serious
side effect of sildenafil.
* Stop using sildenafil and get emergency medical help if you have
sudden vision loss.
* Get emergency medical help if you have any of these signs of an
allergic reaction: hives; difficulty breathing; swelling of your
face, lips, tongue, or throat.
* Stop using sildenafil and call your doctor at once if you have
any of these serious side effects:
o chest pain or heavy feeling, pain spreading to the arm or shoulder,
nausea, sweating, general ill feeling;
o irregular heartbeat;
o swelling in your hands, ankles, or feet;
o shortness of breath;
o vision changes;
o feeling light-headed, fainting; or
o penis erection that is painful or lasts 4 hours or longer.
* Continue taking sildenafil and talk with your doctor if you have
any of these less serious side effects:
o warmth or redness in your face, neck, or chest;
o stuffy nose;
o headache;
o upset stomach; or
o back pain.
* Side effects other than those listed here may also occur. Talk
to your doctor about any side effect that seems unusual or that
is especially bothersome.
What other drugs will affect sildenafil?
* Do not take sildenafil if you are also using a nitrate drug
for chest pain or heart problems, including nitroglycerin (Nitrostat,
Nitrolingual, Nitro-Dur, Nitro-Bid, Minitran, Deponit, Transderm-Nitro),
isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), and isosorbide
mononitrate (Imdur, ISMO, Monoket), or recreational drugs such as
amyl nitrate or nitrite (“poppers”).
* Before taking sildenafil, tell your doctor if you are using any
of the following medications:
o bosentan (Tracleer);
o cimetidine (Tagamet, Tagamet HB);
o an antibiotic such as erythromycin (E-Mycin, Eryc, Ery-Tab) or
clarithromycin (Biaxin);
o doxazosin (Cardura), prazosin (Minipress), Terazosin (Hytrin);
o HIV medicines such as amprenavir (Agenerase), tipranavir (Aptivus),
darunavir (Prezista), efavirenz (Sustiva), nevirapine (Viramune),
indinavir (Crixivan), saquinavir (Invirase, Fortovase), lopinavir/
ritonavir (Kaletra), fosamprenavir (Lexiva), ritonavir (Norvir),
atazanavir (Reyataz), or nelfinavir (Viracept);
o an antifungal medication such as itraconazole (Sporanox) or ketoconazole
(Nizoral);
o carbamazepine (Tegretol), phenobarbital (Luminal), or phenytoin
(Dilantin); or
o rifampin (Rifadin, Rimactane) or rifabutin (Mycobutin).
* If you are using any of these drugs, you may not be able to take
sildenafil, or you may need dosage adjustments or special tests
during treatment.
* There may be other drugs not listed that can affect sildenafil.
Tell your doctor about all the prescription and over-the-counter
medications you use. This includes vitamins, minerals, herbal products,
and drugs prescribed by other doctors. Do not start using a new
medication without telling your doctor.
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