Atorvastatin belongs to a class of drugs referred to as statins which includes lovastatin (Mevacor), simvastatin, (Zocor), fluvastatin (Lescol), and pravastatin (Pravachol). It is an oral drug that lowers the level of cholesterol in the blood. They lower total blood cholesterol as well as LDL cholesterol levels. (LDL cholesterol is believed to be the "bad" cholesterol that is primarily responsible for the development of coronary artery disease.) Lowering LDL cholesterol levels retards progression and may even reverse coronary artery disease. All statins, including atorvastatin, prevent the production of cholesterol by the liver by blocking the enzyme that makes cholesterol, HMGCoA reductase. Unlike the other drugs in this class, atorvastatin also can reduce the concentration of triglycerides in the blood. High blood concentrations of triglycerides also have been associated with coronary artery disease. Atorvastatin was approved by the FDA in December of 1996.

Atorvastatin is taken orally. It may be taken with or without food and at any time of day. Starting doses are 10-40 mg. daily. It is prescribed once daily.

Atorvastatin is generally well-tolerated, and side effects are rare. Some of the minor side effects include constipation, diarrhea, fatigue, gas, heartburn, and headache. Rare cases of muscle inflammation (myositis) and breakdown have been reported with other drugs in this class (HMGCoA reductase antagonists), and it is assumed that this side effect also may occur with atorvastatin. Muscle breakdown causes the release of muscle protein (myoglobin) into the blood and accumulation of the protein in the kidney tubules, resulting in kidney failure. Persistently abnormal liver tests during treatment are rare but may require discontinuation of the medication.
Atorvastatin should be used with caution in patients with alcohol or other liver diseases.
Atorvastatin may be used in pregnancy if the physician feels that its benefits outweigh the potential risks. It is unknown whether atorvastatin affects the fetus during pregnancy.
Store this medication below or at room temperature, 15-30°C (59-86°F).

When atorvastatin is given together with other medications such as cyclosporine (Sandimmune), gemfibrozil (Lopid), erythromycin and nicotinic acid, the risk of muscle breakdown is increased.

Atorvastatin is used for the treatment of high cholesterol and triglyceride levels. The effectiveness of atorvastatin in lowering cholesterol is dose related, meaning that higher doses reduce cholesterol more. High blood cholesterol is first treated with exercise, weight loss, and a diet low in cholesterol and saturated fats. When these measures fail to achieve enough cholesterol-lowering, medications such as atorvastatin may be added. The National Cholesterol Education Program (NCEP) has published treatment guidelines for use of these medications. These treatment guidelines take into account the level of LDL cholesterol as well as the presence of other factors that increase the risk for coronary artery disease such as diabetes, hypertension, cigarette smoking, low HDL cholesterol level, and family history of early coronary heart disease. Blood cholesterol determinations are performed at regular intervals during treatment so that adjustments in doses can be made.