Venlafaxine is an antidepressant which is included in a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). It affects chemical messengers within the brain. These chemical messengers are called neurotransmitters, and some examples are serotonin, dopamine, and norepinephrine. Neurotransmitters are manufactured by nerve cells and are released by the cells. The neurotransmitters travel to nearby nerve cells and cause the cells to become more or less active. Many experts believe that an imbalance in these neurotransmitters is the cause of depression and also may play a role in anxiety.
Venlafaxine is used to treat major depressive disorder, anxiety, and panic disorder. It may also be used for purposes other than those listed in this medication guide.

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. It should be taken with food at doses specifically directed by your doctor. It may take 4 weeks or more for your symptoms to improve. For best results, keep using the medication as directed. Do not stop using venlafaxine without first talking to your doctor.
For patients with difficulty swallowing tablets or capsules, capsules of Effexor XR can be opened and the contents sprinkled on a spoonful of applesauce. Store this medication in a dry place at 20-25°C (68-77°F) away from moisture and heat.

Like most of the anti-depressant, Venlafaxine can cause nausea, headaches, anxiety, insomnia, drowsiness, and loss of appetite. Increased blood pressure can occur, and blood pressure should be monitored. Seizures have been reported. "If anti-depressants are discontinued abruptly, symptoms may occur such as dizziness, headache, nausea, changes in mood, or changes in the sense of smell, taste, etc. (Such symptoms even may occur when even a few doses of anti-depressant are missed.) Therefore, it is recommended that the dose of anti-depressant be reduced gradually when therapy is discontinued. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.

If it is combined with MAO inhibitors such as Nardil and Parnate, it can be life threatening. There should be a waiting period of 14 days between these two classes (MAO inhibitors and venlafaxine) of medications. Most medications affecting the brain such as venlafaxine have the potential to slow reflexes or impair judgment. Therefore, caution is advised especially early in the course of treatment. Safety has not been established in children below the age of 18 years.

If you exceed the recommended dose of this medicine, seek emergency medical attention. n overdose of venlafaxine can be fatal, especially if taken together with alcohol. Symptoms due to overdose of venlafaxine are dizziness, sleepiness, nausea, and numbness or tingling in your hands or feet.

If you miss a dose of this medicine and you are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Venlafaxine is used for treating depression, depression associated with anxiety, generalized anxiety disorder, and social anxiety disorder. Effexor XR is approved for the treatment of adults with panic disorder.